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Currently ongoing and recently completed clinical trials are summarized in Table 2

In the gut, a distinct microbial signature in SSc patients compared with healthy controls has been documented [167, 168] with indications for a reduction in protective butyrate-producing bacteria and by an increase in proinflammatory noxious genera, especially Desulfovibrio [169]

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10.1186/s12864-015-2061-8 77

Establishing a standardized decellularization protocol is crucial for enabling precise comparisons of outcomes and fostering progress in the field across research groups